Idax proteín

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Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein. Hino S., Kishida S., Michiue T., Fukui A., Sakamoto I., Takada S., Asashima M., Kikuchi A. In attempting to clarify the roles of Dvl in the Wnt signaling pathway, we identified a novel protein which binds to the PDZ domain of Dvl and named it Idax (for inhibition of the Dvl and Axin complex).

2013 May 2;497(7447):122-6. doi: 10.1038/nature12052. Epub 2013 Apr 7. This plasmid is available through Addgene. K03344 IDAX; Dvl-binding protein IDAX 09180 Brite Hierarchies 09182 Protein families: genetic information processing 03000 Transcription factors K03344 IDAX; Dvl-binding protein IDAX Transcription factors [BR:ko03000] Eukaryotic type Zinc finger CXXC CpG-binding proteins K03344 IDAX; Dvl-binding protein IDAX.

Idax proteín

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The degradation of TET2 can also be mediated by the ubiquitin-proteasome pathway that poly-ubiquitination of the C-termi … Dapper and Dishevelled colocalize intracellularly and The Idax protein interacts with the Dsh PDZ domain and form a complex with Axin, GSK-3, CKI, and -catenin. can compete with Axin for Dsh binding (Hino et al., Overexpression of Dapper increases Axin and GSK-3 2001). Axin itself binds to Dsh via heterodimerizing DIX in this complex, resulting in decreased soluble domains present on both proteins … This domain (IDAX in case of TET2) appears to be highly conserved among vertebrates [[45-47]]. The relationship between TET protein sequence motifs and protein function, as well as their phylogenetic relationships, has been recently reviewed in ref. []. Cxxc4 (synonyms: Idax) Protein Name(s) CXXC-type zinc finger protein 4 Inhibition of the Dvl and axin complex protein External Links: UniProt Q9EQC9: EMBL AF272158: UniGene Rn.148586: ProteinModelPortal Q9EQC9: SMR Q9EQC9: BioGrid 249851: IntAct Q9EQC9: STRING 10116.ENSRNOP00000016549: PaxDb Q9EQC9: PRIDE Q9EQC9: RGD 69228: eggNOG NOG78018: … New tumor suppressor CXXC finger protein 4 inactivates mitogen activated protein kinase signaling.

In attempting to clarify the roles of Dvl in the Wnt signaling pathway, we identified a novel protein which binds to the PDZ domain of Dvl and named it Idax (for inhibition of the Dvl and Axin complex). Idax and Axin competed with each other for the binding to Dvl.

can compete with Axin for Dsh binding (Hino et al., Overexpression of Dapper increases Axin and GSK-3 2001). Axin itself binds to Dsh via heterodimerizing DIX in this complex, resulting in decreased soluble domains present on both proteins … This domain (IDAX in case of TET2) appears to be highly conserved among vertebrates [[45-47]]. The relationship between TET protein sequence motifs and protein function, as well as their phylogenetic relationships, has been recently reviewed in ref. [].

PubMed

Idax proteín

PubMed Article Plasmids from Article. ID Plasmid Purpose ; 49446: FH-TET3-pEF: This plasmid … 01/05/2013 Dvl-Binding Protein IDAX (Inhibition Of The Dvl And Axin Complex) 1 2: Inhibition Of The Dvl And Axin Complex Protein 2 3: CXXC Finger 4 2: CXXC-Type Zinc Finger Protein 4 2: External Ids: HGNC: 24593 1 : Entrez Gene: 80319 2 : Ensembl: ENSG00000168772 7 : OMIM: 611645 5 : UniProtKB: Q9H2H0 3 : Export aliases for CXXC4 gene to outside databases. Previous GC identifiers: GC04M105853 GC04M105747 … This gene encodes a CXXC-type zinc finger domain-containing protein that functions as an antagonist of the canonical wingless/integrated signaling pathway. IDAX was originally encoded within an ancestral TET2 gene that underwent a chromosomal gene inversion during evolution, thus separating the TET2 CXXC domain from the catalytic domain. The IDAX CXXC domain binds DNA sequences containing unmethylated CpG dinucleotides, localizes to promoters and CpG islands in genomic DNA and interacts directly with the catalytic domain of TET2. … 1: Idax protein, Xenopus [Supplementary Concept] an inhibitor of the canonical Wnt pathway required for anterior neural structure formation; GenBank AB085700 Date introduced: December 20, 2004 Heading Mapped to: Carrier Proteins Xenopus Proteins Entry Terms: XIdax protein, Xenopus inhibition of the Dvl and Axin complex protein, Xenopus Modulation of TET2 expression and 5-methylcytosine oxidation by the CXXC domain protein IDAX.

Anti-Idax Antibody Products. Products (9) Write … IDAX: Description: CXXC finger protein 4 (HGNC Symbol) Chromosome: 4: Cytoband: q24: Chromosome location (bp) 104468312 - 104494901: Number of transcripts i. 1: Protein evidence: Evidence at transcript level : Protein class i. Ensembl: ENSG00000168772 (version 92.38) Entrez gene: 80319: UniProt: neXtProt: Antibodypedia : CXXC4 antibodies: PROTEIN BROWSER i.., CXXC4-201. PROTEIN … Plasmid Myc-Idax WT from Dr. Anjana Rao's lab contains the insert IDAX and is published in Nature.

Idax proteín

… 1: Idax protein, Xenopus [Supplementary Concept] an inhibitor of the canonical Wnt pathway required for anterior neural structure formation; GenBank AB085700 Date introduced: December 20, 2004 Heading Mapped to: Carrier Proteins Xenopus Proteins Entry Terms: XIdax protein, Xenopus inhibition of the Dvl and Axin complex protein, Xenopus Modulation of TET2 expression and 5-methylcytosine oxidation by the CXXC domain protein IDAX. Journal: Nature Publication Year: 2013 Authors: Myunggon Ko,Jungeun An,Hozefa S Bandukwala,Lukas Chavez,Tarmo Aijo,William A Pastor,Matthew F Segal,Huiming Li,Kian Peng Koh,Harri Lahdesmaki,Patrick G Hogan,L Aravind,Anjana Rao PubMed link: 23563267 Funding Grants: Generation of regulatory T … The CXXC domains of TET2 (encoded by the distinct gene IDAX) and TET3 are found to have previously unknown roles in the regulation of TET proteins through the activation of caspases and subsequent Anti-Idax antibodies can be readily obtained from commercial sources. The Idax protein is a reported synonym for the human gene CXXC4, encoding CXXC finger protein 4. The full-length protein is 198 amino acids in length and 20978 daltons in mass.

CXXC finger 4; CXXC finger protein 4; CXXC type zinc finger protein 4; CXXC- type zinc finger protein 4; Cxxc4; CXXC4_HUMAN; Dvl binding protein IDAX  binding protein which has an extremely high affinity for biotin. CXXC finger 4; IDAX; MGC149872; Dvl-binding protein IDAX (inhibition of the Dvl and Axin. 4 Jun 2019 Here, we showed that AMP-activated protein kinase (AMPK) mechanisms: (a) the binding protein IDAX (CXXC finger protein 4) of TET2 can  CXXC-type zinc finger protein 4 antibody; Cxxc4 antibody; CXXC4_HUMAN antibody; Dvl binding protein IDAX (inhibition of the Dvl and Axin complex) antibody  IDAX series are smaller, lighter, faster and maintains better accuracy and ability to provide reliable data using true AC DFR (Dielectric Frequency Response),  anti-CXXC Finger Protein 4 (CXXC4) (AA 164-194), (C-Term) antibody Primary 9330210J02Rik antibody; C030003J12Rik antibody; IDAX antibody; xIdax  by Dr. Anjana Rao's group, IDAX was shown to target TET2 for degradation ( Lin's group showed that the kinase IKK inactivates BAD protein by phosphoryla. CXXC5 is zinc finger protein closely related to the DVL1-binding protein CXXC4 ( also known as Idax), and like CXXC4 is thought to modulate the Wnt signaling  inducing activity of TET protein is independent of its enzymatic activity. N- terminal CXXC domain, while TET2 CXXC domain IDAX. (also known as CXXC4) is  7 Jun 2019 The CXXC4 (IDAX) protein binds to CpG islands and recruits TET2, resulting in the latter's degradation.

Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein. Hino S., Kishida S., Michiue T., Fukui A., Sakamoto I., Takada S., Asashima M., Kikuchi A. In attempting to clarify the roles of Dvl in the Wnt signaling pathway, we identified a novel protein which binds to the PDZ domain of Dvl and named it Idax (for inhibition of the Dvl and Axin complex). Anti-Idax antibodies can be readily obtained from commercial sources. The Idax protein is a reported synonym for the human gene CXXC4, encoding CXXC finger protein 4. The full-length protein is 198 amino acids in length and 20978 daltons in mass. Visit the antibody supplier page for key details, including validated applications and target PubMed Protein expression was chemically induced by the addition of isopropyl-1-thio-β-d-galactoside (IPTG) to a final concentration of 1 mM and the cells were harvested 6 h later by centrifugation. Production of unlabeled rat Idax.

Since this Dvl-interacting protein is a novel protein, we designated it Idax (for inhibition of the Dvl and Axin complex). The mRNA of Idax was highly expressed in cerebrum, cerebellum, and heart and was slightly expressed in thymus and testis among rat tissues (Fig. (Fig.1B). 1 B). PubMed The protein has a mass of 21 kDa and length of 198 residues. It may be known by other names, including: inhibition of the Dvl and axin complex protein, Dvl-binding protein IDAX (inhibition of the Dvl and Axin complex), CXXC finger 4, and CXXC-type zinc finger protein 4.

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Introduction. Allosteric modulators can alter the affinity and efficacy of other substances acting on a receptor. A modulator may also increase affinity and lower efficacy or vice versa. Affinity is the ability of a substance to bind to a receptor. Efficacy is the ability of a substance to activate a receptor, given as a percentage of the ability of the substance to activate the receptor as compared to the receptor's …

The CXXC domain is highly conserved and responsible for Modulation of TET2 expression and 5-methylcytosine oxidation by the CXXC domain protein IDAX. Nature 2013; 497: 122–126. CAS PubMed PubMed Central Google Scholar 7.